Manahawkin Back Pain Related to Inflammation Reduced with Melatonin
Inflammation. Disc Degeneration. There is a connection. Inflammation acts as the body’s response system to harmful stimuli (injury, pathogens, metabolic stress – a disc herniation pushing on a nerve!) as it attempts to restore itself to normal before the harm was achieved. Manahawkin Chiropractic Center is always amazed at what the body can do! Manahawkin Chiropractic Center sees its Manahawkin chiropractic care as the body’s partner in healing particularly when there is spine pain. Chiropractic care utilizes many tools like spinal manipulation, exercise, and nutrition to help the body. Melatonin is one nutritional tool that is proving value in its ability to interrupt the inflammatory process related disc herniation that results in back pain, neck pain and other spine related pain.
DISC DEGENERATION AND INFLAMMATION AND 'AUTOPHAGY'
Inflammatory markers interleukin-1β (IL-1β), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) are associated with intervertebral disc degeneration. (1) IL-1 β in fact promotes itself, its own expression, by upregulating NLRP3 inflammasome activation. (2) The body regulates itself down to its cellular level via autophagy, the natural process via which the body’s cells clean out damaged (ie, by inflammation) or unneeded parts. In a new study, melatonin increased autophagy and reduced the degradation of the disc’s extracellular matrix (technically indicated by a decrease in marker LC3B, autophagasomes and autolysosomes and inhibition of the NF-kB signaling pathway). The end conclusion was that melatonin inhibits intervertebral disc degeneration by promoting autophagy. (3) Wow. Manahawkin Chiropractic Center is inspired by this research to see just how well melatonin can perform for Manahawkin back pain related to disc degeneration.
MELATONIN AND ITS HEALING WAYS FOR THE DISC
Disc degeneration is a very common malady seen at Manahawkin Chiropractic Center that positive news of melatonin’s benefits are quite rousing. A new study explained how melatonin could modify the extracellular matrix of the disc remodeling process started by IL-1 β. Further, melatonin decreased the inflammatory cell collection and reduced the release of linked inflammatory markers IL-1β, IL-6, and TNF-α. With this new finding that melatonin interrupted the IL-1B feedback loop, researchers suggested that melatonin may contribute to the healing process of intervertebral discs after damage was already present. (1) Manahawkin Chiropractic Center continues following the new research on the role inflammation plays in Manahawkin disc degeneration and melatonin’s role in tackling it.
INFLAMMATION AND MELATONIN
The significance of melatonin in helping to slow or stop painful conditions due to inflammation is rising. The description of melatonin as a multitasking molecule affecting mood, immunity, and energy among other things is quite fitting. It’s also anti-oxidant, anti-aging, and anti-inflammatory, specifically by hindering the activation of inflammasomes (4) Melatonin’s formal chemical name is as about as long as its list of tasks: N-acetyl-5-methoxytryptamine. The pineal gland secretes melatonin naturally. Melatonin impacts the body’s aging, anti-inflammatory, anti-apoptosis (cell death), and autophagy (cell-cleanout) processes. (1) Melatonin’s specific effect on inflammation and disc degeneration is most attention-getting to Manahawkin Chiropractic Center and our Manahawkin back pain patients.
CONTACT Manahawkin Chiropractic Center
Listen to this PODCAST with Dr. Hrefna Sylvia based in Iceland where back pain isn’t much different from any other country on The Back Doctors Podcast with Dr. Michael Johnson as she describes how The Cox® Technic System of Spinal Pain Management addresses disc degeneration for relief of chronic low back pain in her patient.
Schedule your Manahawkin chiropractic appointment with Manahawkin Chiropractic Center soon. We can talk about the role inflammation plays in your back pain experience and how melatonin may help with the related disc degeneration.
